Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection
Identifieur interne : 000D21 ( Main/Exploration ); précédent : 000D20; suivant : 000D22Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection
Auteurs : Mohamed Sarjoon Abdul-Cader ; Upasama De Silva Senapathi ; Hanaa Ahmed-Hassan ; Shayan Sharif ; Mohamed Faizal Abdul-CareemSource :
- BMC Microbiology [ 1471-2180 ] ; 2019.
Abstract
Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, synthetic ssRNA analog, resiquimod, has been shown to elicit antiviral response against infectious bursal disease virus infection. The objective of this study was to determine the innate host responses activated by the pre-hatch
First, we observed that
This study provides insights into the mechanisms of antiviral response mediated by resiquimod, particularly against ILTV infection in chicken.
Url:
DOI: 10.1186/s12866-019-1398-6
PubMed: 30736730
PubMed Central: 6368756
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection</title><author><name sortKey="Abdul Cader, Mohamed Sarjoon" sort="Abdul Cader, Mohamed Sarjoon" uniqKey="Abdul Cader M" first="Mohamed Sarjoon" last="Abdul-Cader">Mohamed Sarjoon Abdul-Cader</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary Medicine, Health Research Innovation Center 2C53,</institution><institution>University of Calgary,</institution></institution-wrap>3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada</nlm:aff><wicri:noCountry code="subfield">AB T2N 4N1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="De Silva Senapathi, Upasama" sort="De Silva Senapathi, Upasama" uniqKey="De Silva Senapathi U" first="Upasama" last="De Silva Senapathi">Upasama De Silva Senapathi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary Medicine, Health Research Innovation Center 2C53,</institution><institution>University of Calgary,</institution></institution-wrap>3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada</nlm:aff><wicri:noCountry code="subfield">AB T2N 4N1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Ahmed Hassan, Hanaa" sort="Ahmed Hassan, Hanaa" uniqKey="Ahmed Hassan H" first="Hanaa" last="Ahmed-Hassan">Hanaa Ahmed-Hassan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary 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Sarjoon Abdul-Cader</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary Medicine, Health Research Innovation Center 2C53,</institution><institution>University of Calgary,</institution></institution-wrap>3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada</nlm:aff><wicri:noCountry code="subfield">AB T2N 4N1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="De Silva Senapathi, Upasama" sort="De Silva Senapathi, Upasama" uniqKey="De Silva Senapathi U" first="Upasama" last="De Silva Senapathi">Upasama De Silva Senapathi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary Medicine, Health Research Innovation Center 2C53,</institution><institution>University of Calgary,</institution></institution-wrap>3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada</nlm:aff><wicri:noCountry code="subfield">AB T2N 4N1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Ahmed Hassan, Hanaa" sort="Ahmed Hassan, Hanaa" uniqKey="Ahmed Hassan H" first="Hanaa" last="Ahmed-Hassan">Hanaa Ahmed-Hassan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary Medicine, Health Research Innovation Center 2C53,</institution><institution>University of Calgary,</institution></institution-wrap>3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada</nlm:aff><wicri:noCountry code="subfield">AB T2N 4N1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Sharif, Shayan" sort="Sharif, Shayan" uniqKey="Sharif S" first="Shayan" last="Sharif">Shayan Sharif</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8198</institution-id><institution-id institution-id-type="GRID">grid.34429.38</institution-id><institution>Department of Pathobiology,</institution><institution>University of Guelph,</institution></institution-wrap>Guelph, ON N1G 2W1 Canada</nlm:aff><wicri:noCountry code="subfield">ON N1G 2W1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Abdul Careem, Mohamed Faizal" sort="Abdul Careem, Mohamed Faizal" uniqKey="Abdul Careem M" first="Mohamed Faizal" last="Abdul-Careem">Mohamed Faizal Abdul-Careem</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7697</institution-id><institution-id institution-id-type="GRID">grid.22072.35</institution-id><institution>Faculty of Veterinary Medicine, Health Research Innovation Center 2C53,</institution><institution>University of Calgary,</institution></institution-wrap>3330 Hospital Drive NW, Calgary, AB T2N 4N1 Canada</nlm:aff><wicri:noCountry code="subfield">AB T2N 4N1 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Microbiology</title><idno type="eISSN">1471-2180</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, synthetic ssRNA analog, resiquimod, has been shown to elicit antiviral response against infectious bursal disease virus infection. The objective of this study was to determine the innate host responses activated by the pre-hatch <italic>in ovo</italic> administration of resiquimod against infectious laryngotracheitis virus (ILTV) infection in chickens post-hatch.</p></sec><sec><title>Results</title><p id="Par2">First, we observed that <italic>in ovo</italic> treatment of resiquimod at embryo day (ED) 18 increases macrophage recruitment in respiratory and gastrointestinal tissues of chicken day 1 post-hatch in addition to interleukin (IL)-1β in lungs. Second, we observed that <italic>in ovo</italic> treatment of resiquimod reduces ILTV cloacal shedding at 7 days post-infection (dpi) when challenged at day 1 post-hatch coinciding with higher macrophage recruitment. In vitro, we found that resiquimod enhances production of nitric oxide (NO) and IL-1β and not type 1 interferon (IFN) activity in avian macrophages. Although, the antiviral response against ILTV is associated with the enhanced innate immune response, it is not dependent on any of the innate immune mediators observed as has been shown in vitro using avian macrophage.</p></sec><sec><title>Conclusion</title><p id="Par3">This study provides insights into the mechanisms of antiviral response mediated by resiquimod, particularly against ILTV infection in chicken.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R Medzhitov</name></author><author><name sortKey="Janeway, Ca" uniqKey="Janeway C">CA Janeway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meylan, E" uniqKey="Meylan E">E Meylan</name></author><author><name sortKey="Tschopp, J" uniqKey="Tschopp J">J 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Durantel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwata, M" uniqKey="Iwata M">M Iwata</name></author><author><name sortKey="Vieira, J" uniqKey="Vieira J">J Vieira</name></author><author><name sortKey="Byrne, M" uniqKey="Byrne M">M Byrne</name></author><author><name sortKey="Horton, H" uniqKey="Horton H">H Horton</name></author><author><name sortKey="Torok Storb, B" uniqKey="Torok Storb B">B Torok-Storb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bose, S" uniqKey="Bose S">S Bose</name></author><author><name sortKey="Kar, N" uniqKey="Kar N">N Kar</name></author><author><name sortKey="Maitra, R" uniqKey="Maitra R">R Maitra</name></author><author><name sortKey="Didonato, Ja" uniqKey="Didonato J">JA DiDonato</name></author><author><name sortKey="Banerjee, Ak" uniqKey="Banerjee A">AK Banerjee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, Cm" uniqKey="Robinson C">CM Robinson</name></author><author><name sortKey="O Dee, D" uniqKey="O Dee D">D O'Dee</name></author><author><name sortKey="Hamilton, T" uniqKey="Hamilton T">T Hamilton</name></author><author><name sortKey="Nau, Gj" uniqKey="Nau G">GJ Nau</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Abdul Cader, Mohamed Sarjoon" sort="Abdul Cader, Mohamed Sarjoon" uniqKey="Abdul Cader M" first="Mohamed Sarjoon" last="Abdul-Cader">Mohamed Sarjoon Abdul-Cader</name><name sortKey="Abdul Careem, Mohamed Faizal" sort="Abdul Careem, Mohamed Faizal" uniqKey="Abdul Careem M" first="Mohamed Faizal" last="Abdul-Careem">Mohamed Faizal Abdul-Careem</name><name sortKey="Ahmed Hassan, Hanaa" sort="Ahmed Hassan, Hanaa" uniqKey="Ahmed Hassan H" first="Hanaa" last="Ahmed-Hassan">Hanaa Ahmed-Hassan</name><name sortKey="De Silva Senapathi, Upasama" sort="De Silva Senapathi, Upasama" uniqKey="De Silva Senapathi U" first="Upasama" last="De Silva Senapathi">Upasama De Silva Senapathi</name><name sortKey="Sharif, Shayan" sort="Sharif, Shayan" uniqKey="Sharif S" first="Shayan" last="Sharif">Shayan Sharif</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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